The film features the most extensive interview Ellis has ever given, and spans his life, from his first memory watching the moon landing as a child, to his recent cross-media success with the film adaptation of Red. Along the way, Ellis’s acerbic wit and core belief in humanity comes across like never before.
Complimenting Ellis’s own words are interviews with his artistic collaborators, friends and admirers from across all media, including actress Helen Mirren, Director Joss Whedon (Buffy The Vampire Slayer), comedian Patton Oswalt, Adult Film Star Stoya, Musician Claudio Sanchez (of Coheed and Cambria), comics writers Matt Fraction and Antony Johnston, and futurist Jamais Cascio. Ellis's comics collaborators like Marvel Comics CCO Joe Quesada, artists Darick Robertson, Ben Templesmith and Phil Jimenez also provide insight into Ellis's mind and creative workings. The film features numerous ambient interludes that spotlight Ellis’s prose and writing from both his online columns and his comics.

A sexy, revealing journey into the heart of erotic comic strips, SEX IN THE COMIX examines the colorful history of a unique and risqué art form. Through special editions by masters of the genre and provocative new works from a young generation of artists, the erotic comic is making a big-time comeback, both serving as an expression of society's most intimate trials and tribulations and exposing our collective fantasies (all via speech bubbles). Featuring legendary, iconoclastic comic creators R. Crumb, Milo Manara and Ralf König, and new wave artists like Aurelia Aurita, Aude Picault and Zep, this colorful and charming documentary takes fans along on a special exploration -- guided by New York comic artist and part-time burlesque performer Molly Crabapple -- into a one-of-a-kind medium.