Carmelita Fuentes is a fiery-Latin singer/dancer in Mexico City who has designs on Dennis Lindsay, an American publicity agent, for unclear reasons, while Lindsay's shiftless uncle Matthew Lindsay aids and abets her every step of the way to the marriage altar.

George Sanders makes his final appearance as crook-turned-detective Simon Templar, a.k.a. "The Saint," in The Saint in Palm Springs. The gimmick in this one is a set of rare stamps, smuggled from England. Wendy Barrie is the true heir to this treasure, and the Saint is engaged to protect her and the stamps. Our hero meets Barrie in a posh Palm Springs resort, where a gang of homicidal thieves have converged to relieve the girl of her inheritance. Three murders and one kidnapping attempt later, the villains are foiled by the Saint, with the aid of his onetime partner in crime Pearly Gates (Paul Guilfoyle). The Saint in Palm Springs is the sixth in RKO's series of films based on the character created by Leslie Charteris.