Bruno Corazzari and his gang are in jail awaiting trial. They hire Fernando Sancho's gang to kill the only witness who then take all the passengers of a stagecoach hostage, in Richard Harrison's inn, because they are unsure which of them is actually the witness.

Steve McGowan has proposed to avenge the death of his father, murdered by one of the followers of Chief Miller. This engages the services of a famous gunslinger called Sabata and instructs him to kill Steve. The fate joins Steve and the Mexican bandit Leon Pompero, and together they decide to defeat the murderous gunman.