A cosmic case of flying saucers, intergalactic intrigue and out-of-this-world romance launches Scooby-Doo! and the Mystery Inc., Gang into their most unearthly adventure ever.

神秘帮会重聚并造访月痕岛，这是一座隐藏着不为人知的秘密的偏远岛屿。达芙妮想要的不仅仅是一个穿着戏服的反派，而且他们得到的比他们想象的要多。

Scooby, Shaggy and Scrappy are on their way to Miss Grimwood's Finishing School for Girls, where they've been hired as gym teachers. Once there, however, they find that not only is it actually an all-girl school of famous monsters' daughters but there's a villainess out to enslave the girls.

著名恐怖小説家邀請史酷比偵探小組到麻州小鎮，等他們到了之後才發現當地鬧鬼，其中最恐怖的鬼魂是會施展巫術的女巫，而且還是小説家的祖先……