两个嬉皮士跑去墨西哥，开着一辆完全由大麻制作而成的货车回美国，而他们居然毫不知情。

Disguised as ice cream vendors, Cheech and Chong make--and subsequently lose--millions of dollars selling a batch of marijuana with an unusual side effect.

切奇．马林和汤米．冲是美国著名的喜剧谐星，也是配合默契的黄金搭档，他们自编自演了五部电影，都以他们所经历的有趣故事为内容，本片是其中之一。描述两名谐星到荷兰参加阿姆斯特丹电影展，不料却碰上毒贩，阴差阳错被人追捕。

一个墨西哥籍的美国人无意中被当成非法移民，给遣返回了墨西哥。他必须冒险重返美国。

Cheech must deal with losing his job, his angry neighbor, and trying to score with sexy Donna. Meanwhile, Chong meets Cheech's cousin Red and the two have a wild time in Hollywood with a big bag of buds and a cool Ferrari. Along the way they meet everyone from Pee Wee Herman to really cool aliens.

《离开我房间》是一部模仿《这就是脊椎穿刺》风格的纪录片，由奇奇·马林编剧和导演。在电影中，他和汤米·庄试图为他们的新奇唱片《离开我房间》完成一张“视频专辑”。