The actors were never told in advance what was in store for their characters. Each new episode was just as much a surprise for them as it was for the viewers.
故事的背景设定在公元2257年，人类已经突破光速，开始大规模星际旅行及在太阳系附近殖民，与多个外星文明接触并有贸易联系。一天，一艘地球联邦的星际驱逐舰在探索未知星际空间的时候遇到一艘不明星船，因为误判对方意图而先敌开火。对方叫明巴利外星族（Minbari），比人类早进化发展几千年，其技术人类无法望其项背。不巧的是地球星船孤注一掷先敌开火的时候把灰色議會議長杜哈的给干掉了（那位老兄其实知道按大设计蓝图，明巴利必须与地球人联合并融合，这次到这里也不是闲逛，而是准备与地球人第一次亲密接触）。于是明巴利对地球开战，摧枯拉朽所向披糜，在对地球本土最后一击的过程中，明巴利却突然停止进攻并宣布投降。总之，停战后地球出资在中立空间建设“巴比伦空间站"，致力星际交流、谈判及和平合作。前面四座都被摧毁或莫名其妙消失，于是有了巴比伦5号。巴5军头Sheridan和明巴利大使笛嵐（Delenn）带领众喽罗，联合火星殖民地抵抗力量反对地球联邦通过谋杀政变而上台的独裁总统，联合各外星文明反击神秘黑暗种类——影族（Shadows），向佛隆人（Vorlon）说不，最终走上独立自主自力更生的发展文明道路。

生活在古希腊的一介平民赫伦发现自己的真实身分是宙斯之子，他的目标则是从恶魔军队手中拯救世界。

约翰·谢里登（John Sheridan）在穿越银河系寻找回家之路的途中，意外发现自己被传送穿越多个时间线和交错现实。在此过程中，他与一些熟悉的面孔重逢，同时揭示了关于宇宙的历史、目的和意义的宇宙新启示。

Susan Ivanova discovers a derelict spaceship in hyperspace. They tow it back to Babylon 5, then strange things start happening. People are being telepathically taken over by aliens from another (third)space.

洛杉矶周边近日来发生了疑似野兽袭击的连续死亡事件，而善良、慈祥的老妇人艾米丽却在此时将家中房间租给了一个眼盲的陌生人。艾米丽的儿子克雷是一名正在跟踪报道连环凶案的记者，在一次探视突患怪病的艾米丽时，意外撞见妈妈和房客深夜外出，并在尾随时发现她和房客变成噬人的怪物……
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An intergalactic fighting competition between champions of various worlds has traditionally been won by a species much larger and stronger than humans. Entering the contest, a human finds he has to battle against not just his opponents and his self-doubts, but the corrupt system. Far in the future, on a distant space station, the legendary Arena is where the best fighters from every planet come to vie for the championship. But for over half a century, no Earthling has been good enough to be a contender. Until out of nowhere, comes an underdog: the great human hope, Steve Armstrong... and the best anyone's ever seen. He's been training all his life for a shot at the big time, but now he's up against some mighty big muscle: a ruthless extra-terrestrial crimelord who'll pull no punches to make sure he stops Steve dead. In the mood for hard-hitting sci-fi action? Arena will knock you out!

巨大隕石雨撞擊地球，彷彿聖經中記載的末世降臨般，城市崩壞，人類文明退化，而所有地表水源也因隕石污染全數無法飲用，在水源逐漸枯竭的情況下，大衛手中僅存的純水成了珍貴的資源，此時他的家人遭到綁架，以此要脅他將水交出，面臨可能被隕石群砸中的危險，大衛必須在險惡的環境中設法救出他的家人。