曼妮（拉斐拉•安德森 Raffaëla Anderson）和女友在郊外抽烟聊天时，四个男人突然把她们拉上车带到一间仓库，轮奸了她们，自此，曼妮深深将男人的此种野蛮粗暴兽性记在了心底。城市的另一处，妓女娜丁（卡伦•巴赫 Karen Lancaume）正在一家简陋的旅馆出卖自己的肉体，她感觉自己不过是案板上被切割的香肠。在酒吧，曼尼一怒之下开枪打死了粗鲁无礼的哥哥，而另一处的娜丁，也因一口大麻掐死了与她合租的女友。在车站不期而遇时，几句简单对话令两人结为精神与生活上的好友，开始了以性和子弹报复男人的征途。

Is pornography an acceptable form of expression - and if so, can distinctions be drawn between different forms of pornography? This documentary raises all of these questions, seeking to provide the answers from the perspective of pro-sex feminism, which asserts that pornography must be wrested from patriarchal control, and that in the hands of women and sexual minorities, it can become a tool of liberation. Director Virginie Despentes (Baise-moi) takes a wide ranging look at the movement and maps the evolution of pro-sex, or "post-porn", from its pioneers like Annie Sprinkle to newer European work like Emilie Jouvet's Too Much Pussy! Filled with roughly two dozen interviews with the likes of B. Ruby Rich, Lydia Lunch, Annie Sprinkle, Catherine Breillat, Del La Grace Volcano, Maria Beatty, Coralie Trinh Thi, Carol Queen, Lynnee Breedlove, Norma Jean Almodovar, and other members of the post-porn movement, Mutantes is part of a very queer feminist revolution. Exploring in comprehensive fashion the various sexual niches of punk porn, queer porn, SandM, and transgender, the film goes a long way toward demystifying a movement that has been several decades in the making.