brain
Principles of Computational Modelling in Neuroscience 豆瓣
作者: Andrew Gillies / Bruce Graham 出版社: Cambridge University Press 2011 - 8
"The nervous system is made up of a large number of interacting elements. To understand how such a complex system functions requires the construction and analysis of computational models at many different levels. This book provides a step-by-step account of how to model the neuron and neural circuitry to understand the nervous system at all levels, from ion channels to networks. Starting with a simple model of the neuron as an electrical circuit, gradually more details are added to include the effects of neuronal morphology, synapses, ion channels and intracellular signaling. The principle of abstraction is explained through chapters on simplifying models, and how simplified models can be used in networks. This theme is continued in a final chapter on modeling the development of the nervous system. Requiring an elementary background in neuroscience and some high school mathematics, this textbook is an ideal basis for a course on computational neuroscience." (Amazon)
"This is a wonderful, clear and compelling text on mathematically-minded computational modelling in neuroscience. It is beautifully aimed at those engaged in capturing quantitatively, and thus simulating, complex neural phenomena at multiple spatial and temporal scales, from intracellular calcium dynamics and stochastic ion channels, through compartmental modelling, all the way to aspects of development. It takes particular care to define the processes, potential outputs and even some pitfalls of modelling; and can be recommended for containing the key lessons and pointers for people seeking to build their own computational models. By eschewing issues of coding and information processing, it largely hews to concrete biological data, and it nicely avoids sacrificing depth for breadth. It is very suitably pitched as a Master's level text, and its two appendices, on mathematical methods and software resources, will rapidly become dog-eared."
Peter Dayan, University College London
My Stroke of Insight 豆瓣
作者: Jill Bolte Taylor 出版社: Viking Adult 2008 - 5
在线阅读本书
A brain scientist's journey from a debilitating stroke to full recovery becomes an inspiring exploration of human consciousness and its possibilities
On the morning of December 10, 1996, Jill Bolte Taylor, a thirty-seven-year-old Harvard-trained brain scientist, experienced a massive stroke when a blood vessel exploded in the left side of her brain. A neuroanatomist by profession, she observed her own mind completely deteriorate to the point that she could not walk, talk, read, write, or recall any of her life, all within the space of four brief hours. As the damaged left side of her brain--the rational, grounded, detail- and time-oriented side--swung in and out of function, Taylor alternated between two distinct and opposite realties: the euphoric nirvana of the intuitive and kinesthetic right brain, in which she felt a sense of complete well-being and peace; and the logical, sequential left brain, which recognized Jill was having a stroke, and enabled her to seek help before she was lost completely.
In My Stroke of Insight , Taylor shares her unique perspective on the brain and its capacity for recovery, and the sense of omniscient understanding she gained from this unusual and inspiring voyage out of the abyss of a wounded brain. It would take eight years for Taylor to heal completely. Because of her knowledge of how the brain works, her respect for the cells composing her human form, and most of all an amazing mother, Taylor completely repaired her mind and recalibrated her understanding of the world according to the insights gained from her right brain that morning of December 10th.
Today Taylor is convinced that the stroke was the best thing that could have happened to her. It has taught her that the feeling of nirvana is never more than a mere thought away. By stepping to the right of our left brains , we can all uncover the feelings of well-being and peace that are so often sidelined by our own brain chatter. A fascinating journey into the mechanics of the human mind, My Stroke of Insight is both a valuable recovery guide for anyone touched by a brain injury, and an emotionally stirring testimony that deep internal peace truly is accessible to anyone, at any time. Questions for Jill Bolte Taylor Amazon.com: Your first reaction when you realized what was happening to your body was one you would expect: "Oh my gosh, I'm having a stroke!" Your second, though, was a little more surprising: "Wow, this is so cool!" What could be cool about a stroke? Taylor: I grew up to study the brain because I have a brother who is only 18 months older than I am. He was very different in the way he perceived experiences and then chose to behave. As a result, I became fascinated with the human brain and how it creates our perception of reality. He was eventually diagnosed with the brain disorder schizophrenia, and I dedicated my career to the postmortem investigation of the human brain in an attempt to understand, at a biological level, what are the differences between my brain and my brothers brain. On the morning of the stroke, I realized that my brain was no longer functioning like a "normal" brain and this insight into my brother's reality excited me. I was fascinated to intimately understand what it might be like on the inside for someone who would not be diagnosed as normal. Through the eyes of a curious scientist, this was an absolutely rare and fascinating experience for me to witness the breakdown of my own mind. Amazon.com: What did you learn about the brain from your stroke and your recovery that your scientific training hadn't prepared you for? Taylor: My scientific training did not teach me anything about the human spirit and the value of compassion. I had been trained as a scientist, not as a clinician. I can only hope that we are teaching our future physicians about compassion in medicine, and I know that some medical schools, including the Indiana University School of Medicine, have created a curriculum with this intention. My training as a scientist, however, did provide me with a roadmap to how the body and brain work. And although I lost my left cognitive mind that thinks in language, I retained my right hemisphere that thinks in pictures. As a result, although I could not communicate with the external world, I had an intuitive understanding about what I needed to do in order to create an environment in which the cells in my brain could be happy and healthy enough that they could regain their function. In addition, because of my training, I had an innate trust in the ability of my brain to be able to recover itself and my mother and I respected the organ by listening to it. For example, when I was tired, I allowed my brain to sleep, and when I was fresh and capable of focusing my attention, we gave me age-appropriate toys and tools with which to work. Amazon.com: Your stroke affected functions in your left brain, leaving you to what you call the "la-la land" of your right hemisphere. What was it like to live in your right brain, and then to rebuild your left? Taylor: When the cells in my left brain became nonfunctional because they were swimming in a pool of blood, they lost their ability to inhibit the cells in my right hemisphere. In my right brain, I shifted into the consciousness of the present moment. I was in the right here, right now awareness, with no memories of my past and no perception of the future. The beauty of La-la land (my right hemisphere experience of the present moment) was that everything was an explosion of magnificent stimulation and I dwelled in a space of euphoria. This is great way to exist if you don't have to communicate with the external world or care whether or not you have the capacity to learn. I found that in order for me to be able to learn anything, however, I had to take information from the last moment and apply it to the present moment. When my left hemisphere was completely nonfunctional early on, it was impossible for me to learn, which was okay with me, but I am sure it was frustrating for those around me. A simple example of this was trying to put on my shoes and socks. I eventually became physically capable of putting my shoes and socks on, but I had no ability to understand why I would have to put my socks on before my shoes. To me they were simply independent actions that were not related and I did not have the cognitive ability to figure out the appropriate sequencing of the events. Over time, I regained the ability to weave moments back together to create an expanse of time, and with this ability came the ability to learn methodically again. Life in La-la land will always be just a thought away, but I am truly grateful for the ability to think with linearity once again. Amazon.com: What can we learn about our brains and ourselves from your experience, even if we haven't lived through the kind of brain trauma you have? Taylor: I learned that I have much more say about what goes on between my ears than I was ever taught and I believe that this is true for all of us. I used to understand that I had the ability to stop thinking about one thing by consciously choosing to preoccupy my mind with thinking about something else. But I had no idea that it only took 90 seconds for me to have an emotional circuit triggered, flush a physiological response through my body and then flush completely out of me. We can all learn that we can take full responsibility for what thoughts we are thinking and what emotional circuitry we are feeling. Knowing this and acting on this can lead us into feeling a wonderful sense of well-being and peacefulness. Amazon.com: You are the "Singin' Scientist" for Harvard's Brain Bank (just as you were before your stroke). Could you tell us about the Brain Bank (in song or not)? Taylor: There is a long-term shortage of brain tissue donated for research into the severe mental illnesses. Most people dont realize that when you sign the back of your license as an organ donor, the brain is not included. If you would like to donate your brain for research, you must contact a brain bank directly. There is also a shortage of "normal control" tissue for research. The bottom line reality is that if there were more tissue available for research, then more scientists would be dedicating their careers to the study of the severe mental illnesses and we would have more answers about what is going on with these disorders. The numbers of mentally ill individuals in our society are staggering. The most serious and disabling conditions affect about 6 percent--or one in 17--adults and 9-13 percent of children in the United States. Half of all lifetime conditions of mental illness start by age 14 years, and three-fourths by age 24 years. For more information about brain donation to the Harvard brain bank, please call 1-800-BRAINBANK or visit them at: www.brainbank.mclean.org If you would like to hear me sing the brain bank jingle, please visit www.drjilltaylor.com!
龍蝦腦與義大利羅曼史:夢與腦 豆瓣
作者: 亞倫.哈伯生 / J. Allan Hobson 译者: 樂為良 / 黃裕美 出版社: 立緒 2010
弗洛依德勇敢的將科學帶進我們的想像世界後一百年,
科學到底對腦有些什麼認識?
他落伍了?還是誤導了?
跨越弗洛依德,夢到底告訴了我們什麼?
弗洛依德相信夢是了解人腦的關鍵,這是對的。他假設任何心理學的基礎都必須建立在腦上,也是對的。
但他沒有這個基礎,只好猜測;而且我發現,他對腦科學(seience of the mind)的貢獻,說好是落伍,說壞則是誤導。
我對他的企圖心敬佩有加,讓我不禁想像依據當代夢的科學他會說些什麼。
本書始於我對弗洛依德所做的一個惡作劇式的白日夢,但它是根據我身為神經科學家專業的路上所做的十三個真實的夢建構起來的。
這十三章中,每一章起頭都有個注釋,有時是草圖,是從夢中醒來盡快畫下的。
數十年前我便做過其中很多夢。對一些人會顯得特別有趣的是,我中風後最近所做的一些夢。中風引發各種對神經官能的微妙影響,以奇妙的方式表現在我的夢中。這些親身經驗結合研究頭腦數十年所得的知識,對弗洛依德勇敢將科學帶進我們的想像世界後一百年,科學到底對腦有些什麼認識,我希望讀者有新的理解。 -------本書作者 / J.Allan Hobson, M.D.
脑电图判读step by step 豆瓣
作者: 大熊辉雄 译者: 周锦华 出版社: 科学出版社 2001 - 7
本中译本分《脑电图判读入门篇》和《脑电图判读病例篇》(简称《入门篇》和《病例篇》)两册,是根据两部同名的日文本1999年第3版翻译而来的。作者大熊辉雄是日本著名神经精神病学教授、临床神经生理学家。
本书内容丰富,系统性强,图文并茂,导联标注清楚,易看易懂,使读者能在较短时间内掌握脑电图的基本原理、操作技术和诊断方法,并了解脑电图领域的最新进展。其脑电图均为等比例,且达14、16导联,国内尚无此同