After learning her boyfriend and colleague was already in a relationship and about to marry another colleague, Takako quits her job and falls into a slump. Her uncle, Satoru, offers her a job and room in his used bookstore in Jinbocho. Despite her initial lack of interest, Takako is slowly drawn into the world of books through contact with the customers who frequent the store.

Kitaro is a half human, half creature who keeps an eye on the human society to save them from the evil attacks from another world. He finds that a magical ball that controls all powers had been brought into the human world, and stops it from falling into the wrong hands.

Eriko – lonely, aimless and self-absorbed – falls for Tamura. Despite knowing that he is waiting for his girlfriend to return from overseas, she requests to enter into a relationship with him for just one year.

《魍魉之匣》改编自京极夏彦百鬼夜行系列的第二部作品。
榎木津礼二郎（阿部宽 饰）经营侦探事务所。一天，原电影明星柚木阳子（黑木瞳 饰）委托其受理她14岁的女儿加菜子（寺岛咲 饰）失踪一案。作家关口巽（椎名桔平 饰）和记者鸟口守彦（Magy 饰）对最近发生的美少女被肢解杀人事件十分好奇，一起前往现场追查，却在路途中迷路而误入一栋奇怪的盒状建筑物。负责侦破连续杀人事件的青木警官（堀部圭亮 饰）乘坐的列车上加菜子被撞下车送往医院。刑警木场修（宫迫博之 饰）强忍疲惫下接手处理案件，却发现加菜子的母亲，正是他暗恋多年的阳子。但日，运送加菜子的救护车和随同车辆消失在了匣馆的领地中。
消失的少女、相模湖分尸杀人案、追查案件的木场和关口、盒子般奇怪的建筑物，到底是什么将他们联系在一起？魍魉，真的只存在人心吗？