MR. RIGHT is a comedy series that follows Bryce as he navigates his life after getting his heart broken on a reality TV dating show. Now he's looking for love in all the wrong places- namely, New York City, where he meets Jane, a workaholic lawyer who seems to have little time and even less interest in him.

山姆是玩世不恭的花花公子，他的麻吉安德魯則是一名婦科醫生。某次派對後，山姆一覺醒來發現自己變成女人了，於是自稱山姆的表妹珊曼莎，接續山姆的工作，這才了解身為女性多不容易，主管對他毛手毛腳，更可怕的是叫作生理期的東西。最要命的是只要想起安德魯，他居然起了生理反應。這是上天的玩笑還是懲罰？