4400 overlooked, undervalued, or otherwise marginalized people who vanished without a trace over the last hundred years are all returned in an instant, having not aged a day and with no memory of what happened to them. As the government races to analyze the potential threat and contain the story, the 4400 themselves must grapple with the fact that they've been returned with a few "upgrades", and the increasing likelihood that they were all brought back now for a specific reason.

在佛罗里达群岛漂泊不定的艾塔·泰格·琼斯梦想着在迈阿密灯红酒绿的亚热带王国里过上好日子。然而，当她家族的毒品走私生意因一场悲剧而破碎后，艾塔踏上了一段危险的旅程，深入迈阿密霓虹闪烁的阴暗角落，这段旅程将定义她是谁，以及她最终能做到什么。

布鲁克林最大公立高中的五名学生为了成功、生存、挣脱枷锁并抓住未来而奋斗。与此同时，他们还要应对一个混乱的世界。