A man wins $50,000 in a card game with gamblers, but is soon found dead and the money missing. Slip and Sach find the money near where the body was discovered, and soon find themselves the target of both the police and the gamblers.

The East Side boxing champion Muggs answers a challenge to a fight against the West Side champ but just before the match he is kidnapped. His friend Danny Lyons takes his place and wins the fight, only to have Mugs believe that Danny was responsible for his kidnapping.

Slip and the gang stray from newspaper work to detective work.

Slip and Sach are in the sidewalk star-gazing business when they see a murder committed in a room at the El Royale Hotel.

A scientist keeps his wife young by killing, stealing the bodies of, and taking the gland fluid from virgin brides.