故事讲述美国电视明星多诺万(基特·哈灵顿饰)偶然与一位远在英国的年轻人结为笔友。随着二人关系被媒体曝光，多诺万的生活也发生了翻天覆地的变化。

Experienced New York Police Detective John Harris is sent to London to help a local task force investigate a series of gangster killings organized by a new player in town, an American. With the help of a young teen wronged by gangsters, Harris navigates London's seedy, drug-fuelled underworld in order to take down its new criminal empire.

《新狂蟒之灾》（英语：Anaconda）是一部2025年美国动作喜剧恐怖片，由汤姆·葛米根（Tom Gormican）执导并与凯文·艾顿合作编剧，《新狂蟒之灾》系列电影的第六部作品，1997年电影《狂蟒之灾》的后设电影。主演阵容包括保罗·路德、杰克·布莱克、史蒂夫·扎恩、坦迪·牛顿、丹妮拉·梅尔基奥和赛尔顿·梅罗。电影讲述一群朋友前往亚马逊拍摄自己版本的《狂蟒之灾》，但一条巨型森蚺却突然出现，破坏了他们的计划，原本轻松愉快的拍摄变成了一场生死搏斗。

Set in 18th-century Venice, the film follows the paths of two unlikely collaborators: a Venetian noble and a castrated singer from Calabria, both trying to succeed in the world of the opera.