Two detectives investigate the strangulation murder of a man whom everyone seemed to like.

Bank teller Mike Donovan (Barry Sullivan) takes the first step on the road to Perdition when he fails to report a $49,000 shortage. Accused of theft, Donovan is fired from his job. He is then prevented from finding other employment by Javert-like insurance investigator Gus Slavin (Charles McGraw). Despite many setbacks, Donovan attempts to clear his muddied name.

Ex-cop Vic Barron crossed the wrong mobsters; his wife and child were killed and he was scarred, framed, and imprisoned. On release, Vic has but one desire, revenge on still-hiding Tino Morelli.

While executing an armored car heist in Los Angeles, icy crook Dave Purvis shoots policeman Lt. Phillips before he and his cronies make off with the loot. Thinking he got away scot-free, Purvis collects his money-crazy mistress, Yvonne, then disposes of his partners and heads out of town. What Purvis doesn't know is that Phillips' partner, tough-as-nails Lt. Cordell, is wise to the criminal's plans and is closing in on his prey.

Questioned as a murder suspect, solid (but drunk) citizen Al Willis attacks his police questioners, is beaten, and swears vengeance against them. Next night, Lieut. Parks is murdered; Willis is the only suspect in the eyes of tough Chief Conroy, who pursues him doggedly despite lack of evidence. The obsessed Conroy is dismissed from the force, but continues to harass Willis, who flees to a sleazy town on the Mexican border. Of course, Conroy follows. But which is crazy, Conroy or Willis?

Marshall "Big Jim" Cole turns in his badge and heads to Wyoming with his family in order to settle on some land left him by a relative. He faces opposition both from a neighbor who wants that land for his own sons, and from a grizzly bear nicknamed "Satan" who keeps killing Cole's livestock.