Derrick, a racially-confused Irishman raised in the hood by a black family is having the worst day ever. Determined to prove to his fed-up mother and would-be girlfriend that he's not a screw-up, he sets out to do one thing right (get some milk) and even that proves to be a challenge! Hilarious encounters with racist red-neck cops, local gangsters and 'flamboyant' pawn shop owners ensue, and along the way Derek shows that he can actually do things for others and maybe even get his own life together.

在上集幸存下来的人被神秘的先知Shot Bus Gus所救，他似乎拥有控制这些畜生的能力，在先知的带领下，幸存者进入下水道，那可通往城市，路上他们得到了空手道专家Jean-Claude Seagal的帮助，并得知这些畜生源自一个叫"The Hive."的地方，于是他们决定发起反击，永远消灭掉这些畜生。