egina is a woman from a poor family and married with and former secretary of the wealthy Hélio. Regina has a block with Hélio and can not have sex with him, in spite of fantasizing kinky sex with every man she meets. She goes to a shrink and while resolving her childhood trauma, Hélio has an affair with his secretary Lúcia and leaves Regina. Later, they meet each other by chance, and the healed Regina finally satisfies Hélio.

In search of a powerful hallucinogenic, five friends embark on a dangerous journey deep into the Amazon. But a bad trip isn't the only threat as they discover when they stumble across the hidden camp of the crazed Dr. Moreau and his murderous animal-human hybrid creations.