明治时期，围绕着日本最大的湖泊·琵琶湖畔的监狱所展开的冒险剧作。被大蛇玩弄于鼓掌之中的—阴家、豺、风魔— 故事中描写了他们的过去以及未来。

不断增长的人口和不断恶化的环境让人类不得不开始考虑起了他们的未来，就这样，“火星地球化”的计划被提上了日程，人们通过向火星地表投放藻类和蟑螂使其颜色变深，如此一来便可吸收阳光提高气温。之后，BUGS1号搭载着六名宇航员，踏上了前往火星的旅程，目的在于生物样本的采集和运送。 　　

令六人以及全人类没有想到的是，火星上特殊的气候令生活在其中的蟑螂发生了变异，它们不仅异化拥有了人类的体魄，还产生了极强的攻击性和战斗能力，几乎是在瞬间，六人全军覆没。幸运的是，一只蟑螂的头部样本被传送回了地球，科学家们研究后决定称其为“火星异种”。出乎所有人意料的是，这种可怕的生物在未来，竟然成为了拯救人类的唯一希望。

曾经约下的“约定”、与各自的“义务”。 政变骚乱后过了一年的巴顿。
新体制的ACCA准备着将要到来的1周年庆祝祭典，监察课的吉恩一行也为此而忙碌着。
令人不安的流言、不变的日常、新的歧路、回忆中的眼神、开始的日子。
在各自的思绪交错之中，停止的时间再度缓缓地开始了转动。 “亲爱的吉恩。那时候，我们想着的是什么来着。这次、能和我说说吗？”

Amidst a blizzard caused by UMA Winter, Billy receives a report on the Autumn battle and learns Undead and Unluck are evolving. Juiz appears, revealing to him that the artifacts are weapons meant to defeat God and that the Ark can only perform one more loop. She urges Billy to join forces once more and stake everything on Unluck to achieve their shared goal: "defeat God." However, Billy declares that they cannot work together. Juiz realizes Billy's true intention—to obtain Ark and Apocalypse—but before she can act, Billy drags them into a brutal clash involving UMAs on both sides. Resolute in their own "justice," Juiz presses forward with her blade, while Billy counters by utilizing other Negators' abilities and his pistol. What is Billy's true objective? Meanwhile, Andy and Fuko, having captured Autumn's core, are en route by air to take down Summer. But Billy anticipates that Juiz entrusted Apocalypse to Andy, and sends assassins to strike the pair from the skies!

　　献给没能成为天才的所有人——。

　　朝仓光一，是在大型广告代理店工作的新人设计师。尽管做着总有一天扬名于世的梦并每天努力工作着……。