Masked luchador "Santo" fights against an evil doctor and his zombie army.

Investigators Conrado and Fernando take a leave of the absence from the police force to track down Fernando's girlfriend Virginia. Virginia, a reporter, has left town and is working undercover as a barmaid in order to interview Refugio Canales, a criminal and small town municipal president. Conrado and Fernando soon call their friend Santo for help.

In the Age of the Inquisitions, 1603, Santo, El Enmascarado de Plata, is being laid to rest by a group of monks. The Black Hood, an axe-wielder and a tormented soul who sold his soul to the devil after losing his love to El Santo, appears at the foot of his tomb and swears to seek his revenge no matter how many centuries it takes. El Santo is the chosen one and is sworn to fight for good and justice at any cost. After he finds his love, Alicia, dead at the hands of the Black Hood, El Santo must trust his faith and use his strength in this battle of good vs. evil.

The vampire women of Mexico have awakened to take their revenge on the descendant of the man who destroyed them shortly after they had emigrated to Mexico during the 19th century.

In his first film El Santo was still referred to as ‘El Enmascarado’. Rendered compliant by a scientist and his gangsters via a serum and mysterious rays, he is forced for the opening act to be a henchman for the evil forces who want to take over the world. The film has great historic value, due also to its impressive exterior shots of pre-revolutionary Cuba 1959.