Young filmmakers trying to hawk a movie titled "Bradykillers" about a serial killer who goes after victims Marcia, Jan, and Cindy meet their screen idol, William Shatner. The two young men, who idolize him and in their fantasies have seen him as a shadowy fairy godfather figure, are alarmed at the reality of the middle-aged non-Captain Kirk man that they meet.

教师艾米•罗伯茨（Christine Taylor 克莉斯汀•泰勒 饰）与男朋友尼克（Shane Brolly 申恩•布罗利 饰）相恋多年，但在尼克求婚的当天，一场车祸搅乱了艾米的生活。尼克的汽车和一辆卡车在十字路口相撞，伤者旋即被送往医院。
对医院存有恐惧艾米为了寻找爱人不得不迎着头皮前来寻找，但找遍医院每一个角落，始终未发现尼克的下落。同样遭遇的还有车祸中的卡车司机卢卡斯•戴伦（Jerry O'Connell 饰），他的妹妹也在这所怪异的医院中神秘消失。艾米和卢卡斯结伴通行，却经历了人生中最为恐怖与难忘的一幕……