Jane and Jackie are driven far beyond the brink of madness after witnessing the brutal rape and murder of their younger sister by a group of marauding college fraternity brothers. Upon the release from an insane asylum, the sisters embark on a relentless search for the guys that raped and strangled their sister. Obsessed with revenge and fueled by a hatred of all men, they kill any man that crosses their path, retaining his severed genitals as a trophy.

Dr. Victor Frankenstein neglects the sexual needs of his frigid and frustrated wife Helena. After Helena gets killed in a horse riding accident, Victor decides to bring her back to life. However, Victor's inept assistant Igor accidentally damages Helena's brain and replaces it with a lesbian's brain, so Helena is now a crazed, aggressive, and predatory vixen with a raging insatiable libido.