欢迎来医院值夜班，但必须警告你：你每天都要同时面对拯救生命的考验和运营一家医院的黑暗真相。如果把这两件事情加在一起，你大概就不会认为这是一份可以展现「英勇之举」的好差事了。在圣安东尼奥纪念医院，值午夜班和凌晨班的人通常是一群「特殊品种」——特别是容易兴奋的T.C. Callahan（Eoin Macken）。他曾是个军医，去过残酷的中东战场。但是他很快就会发现一个事实：最艰难的战斗并非发生在战场上，而是在一所真正的医院里，在自己的家中。

It was reported that in season 2, Dixon and Silver's relationship will suffer due to two new characters, Sasha, an African-American woman who pursues Dixon, and Teddy, a tennis champ who pursues Silver and later Adrianna. Annie will also go through hard times and feel isolated from the group, Dixon will abandon her because he gets "sick of her drama" when nude photos of her surface. Silver will reconnect with old friends Adrianna and Naomi.
Season two has also been reported to be darker than season one, taking the viewer far further than the famous but fabled Peach Pit. Like in its NYC counterpart, Gossip Girl, 90210 season 2 will be exploring L.A.'s social scene, using real clubs and restaurants for scenes of drama. The fashion of the show will also change, being more incline to Gossip Girl 's, where the outfits are chic and trendy. Season 2 kicks off on September 8, 2009 at 8:00pm on The CW.