作家兼教师艾瑞斯（娜奥米·沃茨饰）原本在纽约过着安稳而独居的生活，但当她最亲密的朋友兼导师（比尔·默瑞饰）突然去世，并将他心爱的150磅重的大丹犬留给她时，她的生活被彻底打乱了。这只高贵却难以驯服的巨兽——阿波罗，不仅带来了诸多现实问题，比如家具被毁、房东的驱逐通知，还引发了更深层的困扰：它庞大的身影不断提醒艾瑞斯，她的朋友在生前和死后都做出过许多充满问题的选择。然而，随着艾瑞斯与这只狗意外地建立起深厚的情感联系，她也逐渐学会直面自己的过去，接受失去朋友的事实，并重新发现自己内在的创造力。

Harriet, a comic book artist with a secret, and her reckless BFF, Reba, take their '76 AMC Pacer on the open road and instead get a wild ride towards an impending nuclear apocalypse.

An astrophysicist, after making an extraterrestrial discovery, is forced to flee with his family from their home and is chased through the countryside by an anonymous pursuer.