事业成功广受欢迎的喜剧演员乔治•西蒙斯 发现自己身患白血病，决定趁有生之年重返单口笑话表演舞台。在一次表演中乔治结识了单口笑话表演爱好者艾拉。穷困潦倒的艾拉一直梦想成为一名职业单口笑话演员，付不起房租的他一直借住朋友电视演员马克 的客厅，同住的还有单口笑话表演爱好者利奥。艾拉被乔治雇佣成为私人助理，说服乔治将患病消息通家人与前未婚妻劳拉。乔治的白血病在新型实验药物的作用下得到控制，惊喜的他与艾拉前往旧金山表演，在城北马林县家劳拉家中二人旧情复燃。但劳拉的丈夫克拉克 此时突然返家，一切变得尴尬又糟糕……

"Two Stupid Dogs" follows the lives of two dogs: the overly excited Little Dog (the dachshund) and easy-paced Big Dog (the sheepdog). These crazy canines don't know how to fit in the world, and they definitely don't have any know-how. They often find themselves in commonplace situations (going to the drive-in, walking through the mall, working on the farm), some not so common situations (stuck on a space shuttle, a contestant on a game show, getting mistaken for the prime minister) and even in some familiar situations (little red riding hood, Noah's ark, and Hanzel and Gretel). But no matter the situation, their stupidity usually leads them to calamitous results. Written by van_whistler@hotmail.co.uk