Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.

In 1927 Hollywood, a silent film production company and cast make a difficult transition to sound.

A former Secret Service agent grudgingly takes an assignment to protect a pop idol who's threatened by a crazed fan. At first, the safety-obsessed bodyguard and the self-indulgent diva totally clash. But before long, all that tension sparks fireworks of another sort, and the love-averse tough guy is torn between duty and romance.