Terror and death plague a gloomy, coastal metropolis, as a vampiric entity known as 'Pharisee' feeds on the blood of the city's populous. As the police struggle to find the blood-thirsty maniac, a deranged escort named Zoe is unwillingly brought into his world in this bloody rock and roll fueled nightmare.

On the depraved streets of Cleveland, young women are dealt hard lives. Trudging through days of filth, poverty and crime, they do what they can to survive.

While shooting a documentary on the suspicious disappearances within the homeless community, a filmmaker and his crew go missing while uncovering a terrifying and vicious secret below the city's surface.

Crawldaddy and her two kids are travelling across the country on the search for victims. The dysfunctional family has the disturbing habit of skinning people alive before killing them. When their van breaks down, they are put up by a friendly couple.

While on a stakeout, hardboiled cop Eddie Boone gets injected with a dangerous new designer drug causing nightmarish side effects. As he searches for his missing partner, Eddie discovers the urban streets full of mutants, monsters, and mayhem orchestrated by the mastermind behind the lethal narcotic.