影片改编自2004年蒂娜·菲编剧的同名电影和百老汇音乐剧，故事讲述新转学来的女孩Cady Heron（安格瑞·赖斯 Angourie Rice 饰）如何与“校园女王”Regina George（芮妮·拉普 Reneé Rapp 饰）展开竞争、取而代之。同时她必须学会如何在高中这个最残酷的丛林中保持真实的自己。
影片片名其实是“刻薄女孩”的意思，这正是蒂娜·菲创作本片的初衷——有时候对女性最刻薄的反而是女性。

Rhea lives with her tight-knit multigenerational family. After her mother’s death, she has been her father’s emotional rock, and her life revolves around her family’s restaurant, her eclectic group of friends, and her after-school coding club. Everything changes when she falls for aspiring DJ Max and a long lost passion for music is reignited. Rhea discovers that she has a natural gift for creating beats and producing music that blends her Indian heritage, but must find the courage to follow her true inner talent.