Jacob Two Two Meets The Hooded Fang is about a young boy who strives to be heard. He is nicknamed "Two-Two" for having to say things twice to be heard. One day, he decided to buy the groceries for his parents. There is a misunderstanding by the clerk, so Jacob finds himself in court. He is sentenced Two Years, Two months, two weeks, two minutes and five seconds in the Children's Prison hundreds of miles away from civilization. It is a dark, dirty dungeon-like place where the children work and are kept in cells. There are the three head characters, Master Fish, a fish/human, Mistress Fowl, a bird like woman and the Hooded Fang himself. They also have green henchmen who spray "slime resistors" at the children to prevent them escaping. Two child agents try to help him out, as the children also come up with a plan for escape.

An unwed mother-to-be marries a total stranger so he can avoid the draft. She now has a father for her child and he doesn't have to go to Vietnam. But this marriage-of-convenience leads to a romance between the two.

Despite being imprisoned, tek lord Sonny Hokori manages to run his drug empire. A virus, which is not only effective on computer software but also on physical beings, is activated in the global computer network. While Jake Cardigan tries to stop Hokori and his allies, he also has to deal with his former wife's new husband trying to adopt his son.