年轻的心理医生比尔（布鲁斯·威利斯 Bruce Willis 饰）因为病人蜜雪在他面前跳窗自杀，深受打击。为了抚平自己波动的情绪，他来到洛杉矶，找到他的老友鲍伯。鲍伯也是心理医生，他将一些病人聚在周一训练他们能舒坦的面对其它人，但次日，鲍伯被残酷地谋杀了，身中38刀。比尔开始调查，发现一名叫萝丝（珍·玛奇 Jane March 饰）的神秘女子，比尔找到萝丝，得知她患有三重分裂人格，并受人控制。原来控制萝丝的竟然是她的哥哥，她的哥哥由于痛失自己的亲弟弟，于是，强迫萝丝装扮成已死的弟弟。当比尔发现了这一切，萝丝的哥哥也开始向他下手了 ······

Vint is in a troubled marriage. After taking a road trip with his wife they are abducted leaving him for dead and his wife missing. Months later he awakens from a coma, returns home and starts to get his life back in order. Mia his young sister-in-law moves in to take care of him as he recovers. After evidence comes forth and authorities have long given up. The two team up and return to the small town where his wife was last seen. They are led down a violent rabbit-hole where they might not find out the truth behind her disappearance.

一名孤独的拖车司机在路上被逃亡的银行劫匪撞上并劫为人质。劫匪带着他逃入亚利桑那的山中，警方紧追不舍。然而他们很快发现，山林里潜伏着更可怕的存在：嗜食人肉的怪物。如今，罪犯、警察与人质不得不放下对立，为了活过今夜而联手求生。