Yurie is just an ordinary middle school girl in the 1980's - until overnight she finds out that she is a Kami, or God, in the Shinto sense. When Yurie announces this fact to her best friend Mitsue, their classmate Mitsuri takes advantage of Yurie's new divinity to revitalize her family's dying shrine. Yurie is nicknamed Kamichu and now must go on with her godly duties while going to school and winning the heart of her crush, Kenji, while Mitsuri tries to replace her old shrine god Yashima with her.

Years after Minase had defeated Miss Kitami, all the ladies of the Witchcraft School have graduated and have gone their separate ways. The story revolves around Imari who is a psychic investigator leading a team on a murder investigation that will awaken the soul of Miss Kitami within her.