After suffering a heart attack, Bill (Bill Oberst) takes his doctor's advice literally to eliminate the stresses from his life. The plan is working until his killings attract the attention of a psychotic cop (Armand Assante) who isn't sure whether he wants to arrest or join him. Complications deepen when it becomes apparent to Bill that the biggest cause of stress in his life might be his wife.

Helpless to stop a thief from stealing his father’s modest nest egg, Travis grows up blaming himself for his parents’ suicide. Becoming a priest who operates a highway confessional with his ambivalent brother, Michael, he offers sage advice to chosen sinners while raining death on unrepentant thieves. Into the world of this antagonistic duo comes Mary Francis, a deranged young woman with psychopathic tendencies who kills a thief who threatens to expose the decidedly un-holy siblings. Filled with gratitude, Travis invites the woman into their sacred world which begins a chain of carnage-laced events that threaten to destroy the brothers’ bloody, decades-long partnership.

A detective, despondent after the murder of his wife and forced to resign, is brought back to the force when a serial killer appears to be taunting him and turns out to be superhuman.