Police detective Tom Canboro hails from a Christian family. One night, his eccentric brother-in-law Jason seemingly goes insane and tries to kill his wife, calling her a "hater". Canboro realizes this may be a conspiracy going as far as devil worship, but gets in a car crash. Waking in a strange hospital, years have passed and people all over the world are wearing the mark of 666 on their right hands, and those who don't are killed. Franco Macalusso, the believer in global peace, now controls the world, and is trying to bring the world together as it was at the Tower of Babel.

After millions of people vanish and the world falls into chaos, a charismatic leader rises to lead the UN. However, his intentions are more sinister than they appear.

After millions vanish, a group of people must band together to form the Tribulation Force and prepare themselves for the worst seven years the planet has ever seen.

A year and a half ago, the globe was hit with the biggest catastrophe it had ever seen. Without warning and without explanation, hundreds of millions simply vanished off the face of the Earth. The world was in chaos like never before. Yet somehow one man seemed to rise to the challenge. One man had the strength and conviction to unite a shattered world. One man gave the world hope. That man was Nicolae Carpathia, who now rules the entire world.