Margaret Reed, a wealthy and proud woman of Chicago unwillingly finds herself a member of the Donner party - a group of pioneers making their way to California by covered wagon in the summer of 1846. One by one the odds begin to stack against Margaret and her family as precious days slip away and an early winter storm closes the passes through the Sierra Nevada mountain range. Trapped without adequate food and supplies, Margaret struggles to keep her family alive.

The plot chronicles the exploits of Michael, a teenager who is using marijuana and stealing his father's beer. His younger sister, Corey, is worried about him because he started acting differently. When her piggy bank goes missing, her cartoon tie-in toys come to life to help her find it. After discovering it in Michael's room along with his stash of drugs, the various cartoon characters proceed to work together and take him on a fantasy journey to teach him the risks and consequences a life of drug-use can bring and save the world.