Yuji Itadori is a boy with tremendous physical strength, though he lives a completely ordinary high school life. One day, to save a classmate who has been attacked by curses, he eats the finger of Ryomen Sukuna, taking the curse into his own soul. From then on, he shares one body with Ryomen Sukuna. Guided by the most powerful of sorcerers, Satoru Gojo, Itadori is admitted to Tokyo Jujutsu High School, an organization that fights the curses... and thus begins the heroic tale of a boy who became a curse to exorcise a curse, a life from which he could never turn back.

E.U.联盟和布里塔利亚帝国旷日持久的战争在皇历2010年发生转机，帝国派出压倒性的兵力突袭远东日。在很短的时间内，日本这个国家不复存在，从此作为“11区”写入历史。旧日本人民流往世界各地，饱受歧视，心中满是愤懑和不甘。2017年，E.U.联军132部队向圣彼得堡挺进，但遭到帝国军队的围困，面临全军覆没的危险。联军少校蕾拉·玛露卡尔（坂本真绫 配音）将旧日本青年组成非正规军W Zero部队，并提出以这支部队营救132部队的建议。但是在最为凶险的前线，他们不过肩负着牺牲自己来营救友军的悲哀命运。惨烈的对决过后，W Zero部队的中尉日向瑛斗（入野自由 配音）成功完成任务。
而战争还远远未曾结束，新的阴谋与危机浮出水面……