When Lord Menace returns from the dead to terrorize San Antonio, the old gang must reassemble to fight evil once more. Unfortunately, since their last adventure the gang has become complacent. They have families, lives, and weight gain, so how can they fight an otherworldly evil when they first must get in shape?

恶名昭彰的连续杀人狂「兔子男」，在历经多场疯狂杀戮后回到了出生的家乡，正好遇上嗜血的家人在策划新的屠杀行动。他们邀请兔子男加入，却又在行动中利用了他的不堪过去，此举让兔子男的情绪疯狂失控，嗜血的野性再度爆发！当野兽失去理性，就算是家人也可能成为下一个目标。