In Sierra Negra, graverobbers Barraza and Mendoza steal the coffin of Count Karol de Lavud, before heading to a hospital. Barraza sees a medallion upon the coffin's opening and demands more money from Mendoza. Meanwhile, Marta González, recovering from traumatic events, works as a nurse with Dr. Saldívar. When Barraza removes the wooden stake in order to steal Lavud's medallion, the vampire returns to life and begins a crime spree, hunting down Marta to marry her.

1661年，在墨西哥，阿斯塔拉（Astara）的维提利乌斯（Vitelius）男爵因巫术、招魂术和其他罪行被墨西哥宗教裁判所判处火刑。在他临死之际，男爵发誓要向宗教裁判所的子孙后代复仇。300年后，一颗曾在男爵被执行死刑之夜掠过天际的彗星再次降临地球，带来了男爵的化身：一个可怕的、食脑的怪物，他对宗教裁判官的子孙后代进行恐吓。