女儿失踪 20 年后，酒鬼Darlene Hagen正准备与她最好的朋友Gretchen一起举家庆祝圣诞。
平安夜，Darlene疏远的前姐夫Jack不请自来，带着怀旧的礼物和一个沉重的秘密。
很快，Darlene发现自己困在理智和无情的本能之间，陷入了一场危险的风暴。一场斗智斗勇的游戏逐步升级为一场暴力的复仇。

In the strange limbo of 1940, on a dilapidated hotel verandah perched high in a rainforest above the west coast of Mexico, a group of lost souls collide - a defrocked priest turned tourist guide, the grieving widow who runs the hotel, a family of jubilant Nazis and an itinerant portrait artist with her 97 year old poet grandfather. The result is an epic battle between flesh and spirit, captivity and freedom, art and faith, heightened by a tropical rain-storm.

阿历斯（阿诺•施瓦辛格 Arnold Schwarzenegger 饰）和拉里博士（丹尼•德维托 Danny DeVito 饰）研究了一种新的生育配方――安胎灵，它能大大降低女性怀孕的风险。但这种药却没有获得联邦药物处的人体试验批准，所以一直不能上市。资助方将资金和设备都抽走了，无奈两位博士被竞争对手兼顶头上司诺亚安置到女博士黛安娜（艾玛•汤普森 Emma Thompson 饰）手下协助工作。拉里博士为了他们的产品能顺利上市，偷偷将黛安娜冷藏在实验室准备做实验用的卵子和阿历斯的精子结合成受精卵，并劝服了阿历斯在体内植入受精卵，这下，世界上第一例男人受孕就诞生了！阿历斯开始服用他们的产品安胎灵，他们打算在胎儿3个月的时候就将其取出。然而，随着阿历斯服用的安胎灵越多，他各方面都开始出现女性的特征，而且，他开始决心要将胎儿生下来……

Shortly after the Civil War, a man pulls himself out of a grave in the South wearing Southern clothing but carrying Northern gold and carrying a US Army revolver. He has no memory save for some gorgeous brunette and being beaten over the head by a man in a derby. He calls himself "Lazarus" after the man Jesus resurrected until he can figure out who he is and why he was buried alive and left for dead.