In the first feature-length animated movie based on the Hanna-Barbera series, Jonny Quest fans get to meet the women behind the adventurous men. Joining scientist Benton Quest, his plucky son Jonny, bodyguard Race Bannon and Jonny's young pal Hadji are Benton's biologist wife Rachel, Race's ex-wife Jade and young 12-year-old Jessie, who harbors a big secret. Throughout, Team Quest battles the evil schemes of modern-day alchemist Dr. Zin, who has cloned himself and created an army of mutant reptiles in the Peruvian rain forest. The clash there results in a tragedy that changes Jonny's life forever - and later leads to a worldwide pursuit of Zin that includes examining rare Leonardo da Vinci documents in Paris, exploring the Roman catacombs and a final confrontation in the Australian outback.

One spring, Yogi Bear and Boo Boo Bear awake from hibernation to discover three orphaned bear cubs left at the front door of their cave. Despite their initial reservations, Yogi and Boo Boo take the bear cubs into their home and take care of them. Meanwhile, Jellystone Park has gone over budget and the park commissioner orders Ranger Smith to close it down. This means that Yogi, along with the other bears at the park, must be sent to a zoo. Because Yogi can't stand the thought of being cooped up in a zoo for the rest of his life, he hatches an elaborate escape plan. Salvaging car parts from a failed fishing expedition, he constructs a getaway "Supercar," complete with a picnic basket rumble seat for the three orphaned cubs. Together they make their escape from the park to find a new home.

After the death of Shaggy's Uncle Beaureguard, he, Scooby and Scrappy arrive at the late uncle's Southern plantation to collect the inheritance. But as soon as they arrive, they find it is haunted by the ghost of a Confederate soldier. With this spook on their tails while they solve riddles in search of the inheritance, they seek help from the Boo Brothers, a trio of ghost-exterminators to help catch this nasty ghoul.