某天，托马斯（Bernard Letrou 饰）、马克和布丽切特（Solange Pradel 饰）三个年轻人来到法国某个乡村，他们此行的目的是寻访当地一个流传已久的传说。相传在法国路易十五时期，当地出现四个吸血鬼姐妹。四姐妹美艳非常，却残酷冷血。男人们与吸血鬼姐妹进行斗争，最后反被悉数遇害。不过，其中一个女吸血鬼还曾被村民强暴。托马斯他们并不相信这个传言，在他们看来，那四个女孩可能是患有某种病症的人类……
本片是法国僵尸片导演让•洛林（Jean Rollin）的首部长片，亦被其称为法国第一部僵尸电影。影片原本是40分钟的短片，为便于院线放映，让•洛林按照发行放的要求重新补拍了后面的部分。

One night on a deserted street, Pierre (Olivier Martin of Rollin's LA VIOL DU VAMPIRE) runs into a scantily clad mute young woman (Caroline Cartier) who is being pursued by men in tuxedos and bizarre animal masks who kidnap her and take her back to a townhouse that belongs to Pierre's father, industrialist Georges Radamante (Maurice Lemaître) who warns Pierre to mind his own business. Pierre sneaks into the townhouse for one of his father's parties and witnesses a woman playing Russian Roulette shoot herself and the mute young woman drinks her blood. Pierre delves deeper into the mystery and has to fight off his own father's thugs while Georges and his associates squirrel the young woman off to an isolated country house. Pierre then meets the Grandmaster (Michel Delahaye) of a large group of bizarre looking and acting hippies - of whom the young woman is one of their number - who lay siege to the country house with his help to rescue the girl who it turns out has an unusual connection to Pierre.
Rollin's exploitation films could be seen as the link between the "traditional" French New Wave and the works of the more experimental Alain Robbe-Grillet (whose LA BELLE CAPTIVE quotes images from the later half of this film) with its surrealist-on-the-cheap touches and decadent Russian Roulette-playing upper class versus communal vampire hippies plot. Not as explicitly erotic as Rollin's later films - like LA VIOL DU VAMPIRE, LA VAMPIRE NUE still uses nudity as a teasing element - this is still quintessential Jean Rollin in its triumph of imagination over budgetary limitations.