Mallory is the head of an elite government-run strike force dedicated to combating the supernatural. Her team includes the drag queen Vena Cava, an explosives expert; a mute, pre-teen telepath capable of possessing others named Talking Tina; and an armed governmental agent named Durand.

A young man with cystic fibrosis, along with the sister of a fallen friend, goes in search of a legendary healing shrine in Mexico.