Isidora, an old woman, discovers that her mind is quickly deteriorating. At an apparently relaxed dinner table, she will desperately try to hide her state from her daughter, a demanding woman who awaits any sign of senility in order to take way everything she has.

Jamie is a boorish, insensitive American twentysomething traveling in Chile, who somehow manages to create chaos at every turn. He and his friends are planning on taking a road trip north to experience a legendary shamanistic hallucinogen called the San Pedro cactus. In a fit of drunkenness at a wild party, Jamie invites an eccentric woman—a radical spirit named Crystal Fairy—to come along.