In this sequel, two juvenile detention officers must escort a group of criminally-inclined urban kids to the country where they are being forced to renovate a shelter for teens as punishment for their crimes. After one of them is shot by a local, the survivors seek refuge in the home of a voodoo woman, where they mistakenly summon legendary clown-faced demon Killjoy who begins hunting them down one by one.

When Kate discovers she has a terminal illness, she persuades boyfriend Andy to visit Groom Lake, a reputed hotbed of alien activity, hoping to discover proof of life beyond this terrestrial sphere. Soon, the pair crosses paths with desperate government scientists, eccentric locals and a surprising -- and inspiring --conspiracy of epic proportions.

故事发生在美国境内，一场原因不明的病毒侵袭了美洲地区，使死人复活并猎杀活人。很长一段时间后，丧尸虽然还在横行街头，但人们似乎逐渐忘却了他们的恐怖，并开始了新的生活。此时美国成立了一只“丧尸专杀队”来消灭存活的丧尸。政府以为这样就可以维持人类的秩序，可他们错了，丧尸的数量并没有因此而减少，反而更激起了其嗜血兽性，并被某个神秘邪教组织变相利用... ...丧尸专杀队员们不仅要面临死人的威胁，还要提防人心的背叛，他们到底如何才能脱离险境？