Loosely based on Kirstie Alley's real life struggles, this unscripted reality/comedy hybrid follows a semi-fictional film and TV star, in an ongoing attempt to find work and love in the cruel environment of Hollywood. Kirstie comically contends with an unforgiving public and media in the wake of her struggles with weight.

节目会请一些嘉宾来讨论当前政坛和媒体上的事件。与之前节目不同的是，马赫脱口秀请到的嘉宾往往对所讨论问题有比较充分的认识，嘉宾中演员和名人比较少。另外，很多嘉宾是以卫星连线的形式参与的。
节目的长度约为一小时，在摄影棚内有观众现场观看，东部时间每周五晚十点直播。节目源自于洛杉矶CBS电视台的第33摄影棚（“Bob Barker摄影棚”）。春季（二月到五月上旬）约播出12集，秋季（八月下旬到十一月）也播出数量相当的集数。由于节目针对的是时事，所以HBO电视台一般在节目间歇的月份不会安排重播，但偶尔如果有一周节目不播的话，会安排重播之前的节目。

Comedian and best-selling author Greg Behrendt stifles the sound of the dying hipster deep inside as he deconstructs the popular perception of "cool" while simultaneously re-defining the concept of "adulthood" in this stand up performance captured live at the Improv in San Jose.

In an exuberant half-hour from 2002, Patrice O’Neal goes after the real ways we all feel about sex, race, and each other.

Kathy Griffin talks about her Emmy acceptance speech, Larry Craig, Paris Hilton, Paula Abdul, and "The View" (1997). Filmed live at the Chicago Theater - 175 N State St, Chicago, Illinois, USA