Perfume creator Satin Chau is about to reveal her new designer scent, 'Puppy,' when she is cruelly struck down by a rare condition called anosmia, which robs her of her sense of smell and could even kill her. With time fast running out, she begins a frantic search for the only people who can provide the tissue-donations she desperately needs: her long-lost sisters, Corduroy and Velour.

Pee-wee Herman and pals are celebrating Christmas in the Playhouse in their own creative ways: Pee-wee makes a list for Santa Claus 1.5 miles long, teaches Little Richard how to ice skate, goes for a sleigh ride with Magic Johnson, enslaves Frankie Avalon and Annette Funicello into making Christmas cards, receives a long phone call from Dinah Shore, even has more musical fun with k.d. lang, the Del Rubio Triplettes and Charo! Finally, Big Red arrives and announces that Pee-wee's Christmas list was so big, he didn't have enough presents for all the children of the world. Will Pee-wee follow his own advice and help others?