A month after the events of 30 Days of Night (2007), prison nurse Sara Maguire is attacked by a vampire during a prisoner transfer and begins to turn, while her ex-cop brother Nick hunts for her, encountering escaped vampire hunter George Fowler along the way.

Diane Walters, an over-burdened mother of two with a third child on the way, strives to create the perfect Christmas while her loving but dysfunctional family falls apart around her.