It's the summer before 6th grade, and Clark is the new-in-town biracial kid in a sea of white. Discovering that to be cool he needs to act 'more black,' he fumbles to meet expectations, while his urban intellectual parents Mack and Gina also strive to adjust to small-town living. Equipped for the many inherent challenges of New York, the tight-knit family are ill prepared for the drastically different set of obstacles that their new community presents, and soon find themselves struggling to understand themselves and each other in this new suburban context.

根据畅销吸血鬼小说《南方吸血鬼》（Southern Vampire）改编。 人们害怕吸血鬼的时代已经过去，如今是变成吸血鬼害怕人类。在路易斯安纳州的小镇Bon Temps上，电视谈话节目日日讨论到底要不要让吸血鬼合法权益通过，赞成的人和反对的人态度一样激烈。吸血鬼不需要再通过吸人血或者是动物的血来维生，而是去购买由日本人出产的——真血（true blood）。 我们的女主角Sookie Stackhouse（Anna Paquin 饰）是小镇上普通的女招待，她不普通的地方在于她能听见人们心底的话音，这个特异功能不但让她备受困扰，更令她数次恋爱失败。当她与Bill Compton（Stephen Moyer饰）相遇时，她惊喜地发现她听不见对方内心的声音！Bill 是一个吸血鬼，吸血鬼的社会地位不高让他每次出现都好像一个异类，只有善良天真的Sookie从不用异样目光看待他……