一名年轻女子被关押在一个地下医疗机构，在那里，被选中的人被永久肢解，然后用一种实验性的神奇药物治愈：万灵药。

一名計程車司機遭到正被黑道老大追殺的逃犯強行劫持，由此引發一連串緊急事件，使他們兩人的生命都處於危險之中。

As Alyssa and Karla try to escape from the church home that holds them captive, Karla is slaughtered by a vicious, semi-human creature. After Detective Kimball tracks down Alyssa at a rowdy biker bar, she tells Kimball that women inmates disappear every full moon, and shows him the silver bullets in her gun. Now the two must return to the halfway house to confront the priest and nuns—and the snarling, savage evil—that dwell within.