The plot chronicles the exploits of Michael, a teenager who is using marijuana and stealing his father's beer. His younger sister, Corey, is worried about him because he started acting differently. When her piggy bank goes missing, her cartoon tie-in toys come to life to help her find it. After discovering it in Michael's room along with his stash of drugs, the various cartoon characters proceed to work together and take him on a fantasy journey to teach him the risks and consequences a life of drug-use can bring and save the world.

鸡与牛是一个卡通系列剧。故事的主人公牛妹妹是一只拥有神奇力量的小奶牛，平时呆呆傻傻，但是在关键时刻就会变身成“超级牛”，通常她的变身都是为了拯救身为屌丝，但是有点自大和瞧不起妹妹的鸡哥哥。鸡与牛的父母设定成只露下半身的人类，通常都待在家，很单纯和相爱。故事大反派是来自地狱的“没穿裤子先生”（The Red Guy），他的主要任务就是搞破坏，以及调查“超级牛”的来历。
故事中的牛在英语版中变成后就说西班牙语，在国语配音中变身后的主打句是用苏北话说的“超级牛来拯救喽！”该剧和其他卡通频道的节目，如德克斯特的实验室，被收录在cartoonnetwork的What-A-Cartoon!系列中.。