Ensemble cast of off-the-wall Warner Brothers characters, appearing in a wide variety of roles. Wakko, Yakko, and Dot Warner, are WB Studio creations who were just too "zany" to be of any use to the studio. Pinky and the Brain are two mice bent on world domination. Rita and Runt are a cat and dog team, who get into perilous situations every episode, put always seem to find time to sing a song. Bobby, Pesto, and Squit are the Goodfeathers, part of a New York mob of pigeons, who worship Martin Scorsese. Slappy the Squirrel is a late middle-age squirrel; she starred in a series of popular cartoons in the Golden Age. Buttons is a watch-dog, charged with watching the mischievous toddler, Mindy. Chicken Boo is a giant chicken trying to integrate into human society. Flavio and Marita are two urbane hippopotami.

The series takes place in the whimsical world of Jollywood, where Queen Delightful relies on the 7D - Happy, Bashful, Sleepy, Sneezy, Dopey, Grumpy and Doc - to keep the kingdom in order. Standing in their way are two laughably evil villains, Grim and Hildy Gloom, who plot to take over the kingdom by stealing the magical jewels in the 7D's mine. With seven very distinct personalities, the 7D always manage to save the day and send Grim and Hildy running back to their evil lair to try another day.