来自南太平洋萨摩亚群岛的体育记者杜克（约翰尼·德普 Johnny Depp 饰）和他的律师朋友刚佐博士（本尼西奥·德·托尔 Benicio Del Tore 饰）一起开车前往拉斯维加斯，寻找他们的“美国梦”。一路上，他们带了大量毒品和酒精，也遇到形形色色的人，药物作用下，许多迷乱和癫狂的画面出现，让他们分不清幻觉和现实，到底哪个更残破，哪个更肮脏扭曲。两个人的混沌，加上拉斯维加斯本身的纸醉金迷，“美国梦”似乎遥不可及，两个人留下垃圾场一样的五星级酒店房间，无法停止迷幻的路途……

A talented, but unbalanced girl named Foxfur is thrown into a philosophical adventure beyond time and space. Her first goal is to get her friend Khris to drive her to a book store where she's hoping to find some answers, and there she also meets two UFO theorists. She then hears about this thing called The Dead Zone, and she fears that the world she knows might very well be that zone.

On board a long distance spaceship returning to Earth, an alien lifeform has invaded. It feeds off of sexual energy and can clone itself to resemble the female crew members. Once on Earth the government's Alien Files force is called in to investigate the strange behavior of the crew members and to learn why the alien has come to Earth.