El Puma, a Mexican desert guide, escorts an archaeological expedition headed by Professor Lucius Lloyd through the Indian badlands of Mexico. Marian, the professor's niece accompanies the party as only she can translate the Aztec writings in the diary of her father, murdered on a similar expedition six years previous. The professor is murdered by a knife, and the weapon is recognized as the property of El Puma. Magpie, a Federal Investigator, knows that El Puma is really "Lightnin' Bill' Carson, a former federal agent who has been missing since Marian's father was slain. The reluctant Magpie believes that his old pal is guilty. Carson sets out to prove otherwise.

Belle Starr has returned from time in prison only to face a hail of bullets, along with rescue by Hoppy and the Bar 20 gang.

A man has died leaving a fortune somewhere on his ranch. Brandon and his cohorts think a map is hidden in a picture frame. But when they bid on the picture at the auction, newcomer Jerry Lane outbids them. He also buys the ranch so they place their housekeeper there to get the picture. And then to keep Jerry out of the way, they frame him for murder.

A miner who was swindled out of his mine by a banker turns to robbing stagecoaches. Several years after he is tracked down and killed, his son comes to town to tangle with the banker.

Billy Carson and Fuzzy Jones have just collected a reward and Fuzzy indulges in a dream of getting away from the hectic life he has been leading and wants to settle down. They arrive in Red Rock just as the newspaper is being sold at foreclosure and, despite the attempts by Lafe Barlow to intimidate him from bidding. Fuzzy finds himself the owner of a newspaper. Fuzzy meets Edith Martin, daughter of the former owner, and unthinkingly commits himself to carrying on her father's policy of bringing a telegraph line to Red Rock. For reason of his own, Barlow is against this and has his henchmen wage a campaign of terror against the ranchers and citizens. Before long, Billy who had been lazily indifferent to everything connected to Fuzzy and his newspaper, decides to take a hand on the side of the good guys.

Fighter "Scotty" McQuade, contender for the light-heavyweight championship of the Pacific Coast,after being duped by his manager Ted Todd and fight-promoter Lew Slater, is disgusted with the fight game and decides to go back to punching cattle. He gets a job on the ranch owned by Colonel Hayden, where he once again encounters Slater, who has a crooked deal going that will cause Hayden to lose his ranch. With the aid of the Colonel's daughter, Betty Rose, and his pal "Frozen-Face" Cohen, McQuade breaks jail on a framed charge and puts an end to Slater's crooked dealings.

A feud between two gangs in Chinatown breaks out into a tong war.

A cowboy detective goes up against a gang of big-city thugs trying to set up a protection racket out west.

Hopalong Cassidy, boss of the Bar 20 ranch in Texas, rides down the Camino Real in the New Mexico cattle country near Alamogordo, in response to an urgent message from his lifelong sweetheart, Nora Blake, who is in serious trouble. Before he and his saddlemates, "Lucky" Jenkins and "Pappy", can reach her ranch, they are stopped by Clay Allison, a cattle-rustler who is in almost complete control of the district, and wants to extend his holdings by seizing Nora's cattle and driving her out. Seeing Cassidy as a menace to his plans, he has him arrested on a trumped-up charge. Cassidy and his pals shoot their way out of the trouble and reach Nora;s ranch where they learn that Allison's henchmen have murdered her foreman, Tom Dillon, and Allison has sent for a crew of outlaws on the Texas border.

Captain Matthews is paid 40,000 dollars in cash by Nick Conrad for his shipment of silk from China. About 15 seconds after he gets the cash, he's lured away on a false pretence and robbed by Conrad's henchmen. Newspaper reporter Jerry Mason witnesses the robbery and steals the cash from Conrad.

When Decker's gang holds up a stage, henchman Lefty takes a lady's rings. Later lefty accidentally exposes the rings buying ammunition and Cheyenne sees them. When Lefty tries to shoot Cheyenne he is captured. Now Cheyenne wants the rest of the gang and their leader.

A mad scientist changes his simple-minded handyman into a werewolf in order to prove his supposedly crazy scientific theories - and exact revenge.